Irresistible Meatloaf Sandwiches The Perfect Use for Leftovers


There’s something magical about transforming yesterday’s meatloaf into a hearty, comforting sandwich. Whether you're craving a quick lunch or a soul-warming dinner, the meatloaf sandwich hits all the right notes: savory, satisfying, and endlessly customizable. The star of the show? That moist, flavorful slice of meatloaf paired with crisp bread and creamy condiments. Read on for everything you need to know about making the ultimate meatloaf sandwich, as well as a simple recipe for crafting the perfect meatloaf from scratch.

Why You’ll Love This Recipe

  • Versatile and quick: Whether you enjoy it cold or hot, it’s easy to assemble.
  • Perfect for leftovers: Transform your meatloaf into a second-day star.
  • Customizable: Add your favorite toppings, condiments, and cheeses.
  • Comfort food deluxe: It’s hearty, nostalgic, and oh-so-satisfying.

Ingredients for a Meatloaf Sandwich

Essential Components

  1. 2 thick slices of leftover meatloaf
    • The heart of the sandwich, these slices provide rich, seasoned goodness.
  2. 2 slices of bread (toasted, if preferred)
    • Choose hearty bread like sourdough, rye, or classic sandwich bread for the perfect structure.
  3. 1-2 tbsp mayonnaise or your favorite condiment
    • Adds a creamy, tangy layer to balance the savory meatloaf.

Optional Toppings

  • Cheese slices (cheddar, provolone, or Swiss)
    • Melty and gooey for a warm, grilled version.
  • Lettuce, tomato, or pickles
    • Fresh elements add crunch and acidity.
  • Butter (for grilling)
    • Gives a golden, crisp finish to the bread.

How to Make the Perfect Meatloaf Sandwich

  1. Warm the Meatloaf

    • Heat the slices in a skillet over medium heat or microwave for 30-45 seconds until just warmed.
      (Skip this step if you prefer a cold sandwich.)
  2. Prep the Bread

    • Toast the bread lightly for added crunch, or leave it soft for a classic bite.
  3. Spread the Condiment

    • Smear mayonnaise, mustard, or your favorite sauce on one or both slices of bread.
  4. Assemble the Sandwich

    • Place the meatloaf slice on the bread.
    • Add optional toppings like cheese, lettuce, tomato, or pickles.
  5. Optional: Grill the Sandwich

    • For a warm, melty sandwich, heat a skillet over medium heat. Butter the outside of the bread slices and grill until golden brown on both sides.
  6. Serve and Enjoy!

    • Pair with potato chips, a crisp side salad, or a bowl of soup for a complete meal.

Making Fresh Meatloaf for Sandwiches

If you don’t have leftover meatloaf, start with this foolproof classic meatloaf recipe. It’s easy to prepare and guarantees moist, flavorful results.

Ingredients for Fresh Meatloaf

  • 1 tbsp butter: For sautéing vegetables, ensuring a rich base flavor.
  • 3 celery ribs + 1/2 large onion, finely chopped: Adds moisture and texture to the loaf.
  • 2 lbs lean ground beef: The main protein, ideally with 85% lean for balance.
  • 1 cup breadcrumbs: Helps bind the meat mixture.
  • 2 large eggs, lightly beaten: Acts as the glue to hold everything together.
  • 1/4 cup ketchup (+ extra for topping): Adds tangy sweetness to the loaf and glaze.
  • 2 tsp Worcestershire sauce: A depth of umami flavor.
  • 1 tsp garlic powder, 1 tsp salt, 1/2 tsp black pepper: Seasoning essentials.
  • 1/2 cup milk (or beef broth): Keeps the loaf tender and moist.

Step-by-Step Instructions for Fresh Meatloaf

  1. Preheat the Oven

    • Set the oven to 350°F (175°C) and line a baking sheet with parchment or prepare a loaf pan.
  2. Sauté the Veggies

    • In a skillet, melt butter over medium heat. Add celery and onion, cooking for 5-7 minutes until softened. Let cool slightly.
  3. Combine the Ingredients

    • In a large bowl, gently mix the sautéed veggies, ground beef, breadcrumbs, eggs, ketchup, Worcestershire sauce, garlic powder, salt, pepper, and milk.
  4. Shape the Loaf

    • Form into a loaf on the prepared baking sheet or press into a loaf pan.
  5. Add the Glaze

    • Spread a generous layer of ketchup on top for that signature tangy finish.
  6. Bake

    • Bake for 60-75 minutes, or until the internal temperature reaches 160°F. Let the meatloaf rest for 10 minutes before slicing.

Pro Tips for Success

  • Don’t overmix: Combine ingredients just until blended to avoid a dense loaf.
  • Rest before slicing: This locks in juices for clean slices.
  • Use a thermometer: Ensures the perfect doneness without guesswork.

Serving Suggestions

For the ultimate meal, pair your meatloaf sandwich with:

  • Potato chips or fries: The crunch balances the sandwich's softness.
  • A side salad: A fresh green salad or coleslaw provides a refreshing contrast.
  • Soup: Tomato or creamy potato soup complements the sandwich’s richness.

Why This Meatloaf Sandwich Recipe Stands Out

This recipe is simple, versatile, and packed with flavor. From the tender, seasoned meatloaf to the customizable toppings and toasty bread, every bite feels like a warm hug. Whether you’re repurposing leftovers or starting fresh, this sandwich is guaranteed to become a family favorite.